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We harness and explore the biosynthetic creativity of microbes
Goals
We study and engineer host-associated bacteria and their specialized metabolites for in vivo therapeutic and agrochemical applications. We are particularly interested in
- discovering new bioactive natural products from host-associated bacteria
- elucidating unusual pathways for natural product biosynthesis
- unraveling the ecological role and mode of action of natural products
- microbiome engineering for the production of high-value natural products and other therapeutic applications
Our work is multidisciplinary, combining molecular microbiology, synthetic biology, structural biology, metabolomics, enzymology, bioinformatics, analytical chemistry and chemical synthesis.